APOE shRNA Plasmid Expression Vector Set

Name: APOE shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY325
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY325]

Target:: APOE

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Product Overview

Description

A powerful research tool for the potent and specific knockdown of the Apolipoprotein E (APOE) gene, a primary genetic risk factor for Alzheimer's disease. The set includes three sequence-verified shRNA plasmid vectors, each targeting a different region of the APOE mRNA to ensure high knockdown efficiency, along with a non-targeting scrambled shRNA plasmid as a negative control. This ready-to-transfect kit is essential for investigating the role of APOE in amyloid metabolism and neuroinflammation.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

APOE

Full Name

Apolipoprotein E

Gene ID

348

Uniprot ID

P02649

Target Overview

Apolipoprotein E (APOE) is a central protein in lipid metabolism, primarily responsible for transporting cholesterol and other fats. There are three major versions (alleles) of the APOE gene: APOE2, APOE3, and APOE4. The APOE4 isoform is the single most significant genetic risk factor for developing late-onset Alzheimer's disease. Compared to the more common APOE3 form, the APOE4 protein is associated with increased aggregation of amyloid-beta plaques and the formation of tau tangles, both of which are hallmarks of Alzheimer's pathology. This makes the APOE4 isoform a critical target for diagnostic and therapeutic research.

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