Dentatorubral-Pallidoluysian Atrophy (DRPLA) Model-based In Vitro Assay I

Name: Dentatorubral-Pallidoluysian Atrophy (DRPLA) Model-based In Vitro Assay I
SKU: NRZP-0922-ZP1384
Rating: 5 (1 reviews)

[CAT#: NRZP-0922-ZP1384]

Species:: Human

Cell Types:: Neural Stem Cell

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Assay Overview

Description

Creative Biolabs offers custom in vitro functional assays based on neurological disease models. We have a variety of ready-to-use cell models which are validated for disease modeling, drug screening and toxicology testing. We also offer these assays as "cell line models" in a cryopreserved vial. Please feel free to contact us for more details.

Relevant Diseases

Dentatorubral-Pallidoluysian Atrophy (DRPLA)

Cell Models Information

Cell Models Used

iNeu™ Human Neural Stem Cells - Dentatorubral-Pallidoluysian Atrophy (DRPLA) Patient, Donor 40, Cat.#NRZP-0622-ZP67
iNeu™ Human Neural Stem Cells - Dentatorubral-Pallidoluysian Atrophy (DRPLA) Patient, Donor 41, Cat.#NRZP-0622-ZP68
iNeu™ Human Neural Stem Cells - Dentatorubral-Pallidoluysian Atrophy (DRPLA) Patient, Donor 42, Cat.#NRZP-0622-ZP69
iNeu™ Human Neural Stem Cells - Dentatorubral-Pallidoluysian Atrophy (DRPLA) Patient, Donor 43, Cat.#NRZP-0622-ZP70

Cell Models Overview

Dentatorubral-Pallidoluysian Atrophy (DRPLA) is an autosomal dominant spinocerebellar degeneration caused by expansion of CAG repeats encoding polyglutamine tracts in the atrophin-1 protein. Creative Biolabs cell lines derived from patients with Dentatorubral-Pallidoluysian atrophy are an excellent model for studying this rare genetic disorder. Creative Biolabs now offers custom human iPSC-derived brain cells from patients with Dentatorubral-Pallidoluysian atrophy.

Cell Models Control

iNeu™ Human Neural Stem Cells (Male), Source Fibroblasts (74 Yr Donor), Validated, Cat.#NCL-2101-ZP04
iNeu™ Human Neural Stem Cells (Female), Source Fibroblasts (64 Yr Donor), Cat.#NCL-2101-ZP05

Cell Types

Neural Stem Cell

Model Applications

• Studying pathogenesis at the cellular level
• Studying neural network formation and signal transmission in neural culture
• Neurotoxicity testing
• Preclinical drug efficacy testing
• Co-culture studies