GABRA1 shRNA Plasmid Expression Vector Set

Name: GABRA1 shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY340
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY340]

Target:: GABRA1

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Product Overview

Description

A targeted kit for the specific suppression of the GABRA1 gene, encoding a key subunit of the GABA-A receptor. The set provides three validated shRNA plasmid vectors targeting different GABRA1 sequences, plus a non-targeting scrambled shRNA plasmid as a negative control. It enables research into the role of inhibitory neurotransmission in epilepsy and other neurological disorders.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

GABRA1

Full Name

Gamma-Aminobutyric Acid Receptor Subunit Alpha-1

Gene ID

2554

Uniprot ID

P14867

Target Overview

GABRA1 codes for the alpha-1 subunit of the GABA-A (γ-aminobutyric acid type A) receptor. GABA-A receptors are ligand-gated ion channels that serve as the primary mediators of fast inhibitory neurotransmission in the central nervous system. The alpha-1 subunit is the most abundant alpha subunit isoform in the adult brain and is a critical component of receptor assembly and function. These receptors are the target for major classes of drugs, including benzodiazepines and barbiturates. Mutations in the GABRA1 gene that impair receptor function are a known cause of genetic epilepsy syndromes, highlighting the subunit's essential role in regulating neuronal excitability.

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