Creative Biolabs

Mouse Anti-IL-6 Monoclonal Antibody (1A3B4), Unconjugated

[CAT#: NAB20101776CR]

Mouse Monoclonal (1A3B4) to IL-6

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC; WB; ELISA

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Description
Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. IL-6 plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. IL-6 is also considered a myokine, a cytokine produced from muscle, and is elevated in response to muscle contraction. IL-6 has been shown to interact with interleukin-6 receptor and glycoprotein 130. Additionally, IL-6 is involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.
Expression Host
Mammalian cells
Immunogen
IL-6 fusion protein Ag10646
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2b
Clone Number
1A3B4
Applications
IHC; WB; ELISA
Application Notes
IHC : 1:20-1:200; WB : 1:500-1:1000
Relevant Diseases
Neurological Disorders
Research Areas
Neuron
Conjugation
Unconjugated
Form
Liquid
Formulation
PBS, 0.1% sodium azide and 50% glycerol pH 7.3.
Preservatives
Yes
Concentration
1800 μg/ml
Purification
Antigen affinity purification
Purity
>95%, as determined by SDS-PAGE
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store at -20°C. Stable for one year after shipment.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
IL-6
Official Name
IL6
Full Name
Interleukin 6 (interferon, beta 2)
Alternative Names
Interleukin BSF 2;
B cell differentiation factor;
B cell stimulatory factor 2;
B-cell stimulatory factor 2;
BSF 2;
BSF-2;
BSF2;
CDF;
CTL differentiation factor;
Cytotoxic T cell differentiation factor;
Gene ID
3569(Human)
Uniprot ID
P05231(Human)
Neural Proteins & Peptides
Neural Antibodies
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
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