Mouse Anti-NFKB1 Monoclonal Antibody (2G1E3), Unconjugated

NFkB is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFkB is activated by various intra- and extracellular stimuli such as cytokines, oxidant free radicals, ultraviolet irradiation, and bacterial or viral products. NFkB is a family of transcription factors that consists of homo- and heterodimers of NFkB1/p50 and RelA/p65 subunits, and controls a variety of cellular events including development and immune responses. All members share a conserved amino terminus domain that includes dimerization, nuclear localization, and DNA binding regions, and a carboxy terminal transactivation domain. Serines 529 and 536 in the transactivation domain of RelA/p65 are phosphorylated in response to several stimuli including phorbol ester, IL1 alpha and TNF alpha as mediated by IkB kinase and p38 MAPK. Phosphorylation of serines 529 and 536 is critical for RelA/p65 transcriptional activity.

Mammalian cells

NFKB1 fusion protein Ag5832

Human

Monoclonal

Mouse

IgG2a

2G1E3

IF; IHC; WB; ELISA

IF : 1:20-1:200; IHC : 1:20-1:200; WB : 1:500-1:1000

Neurological Disorders

Neural Signal Transduction

Unconjugated

Liquid

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Yes

1000 μg/ml

Antigen affinity purification

>95%, as determined by SDS-PAGE

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Store at -20°C. Stable for one year after shipment.

For research use only, not for diagnostic or therapeutic use.

NFKB1

NFKB1

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

DNA binding factor KBF1;
DNA binding factor KBF1 EBP1;
DNA-binding factor KBF1;
EBP 1;
EBP-1;
EBP1;
KBF1;

4790(Human); 18033(Mouse); 81736(Rat)

P19838(Human); P25799(Mouse); Q63369(Rat)

1. Wang, M., Wang, Z., Zhu, X., Guan, S., & Liu, Z. (2019). NFKB1-miR-612-FAIM2 pathway regulates tumorigenesis in neurofibromatosis type 1. In Vitro Cellular & Developmental Biology-Animal, 55(7), 491-500. 2. Yang, D., Zhang, W., Liang, J., Ma, K., Chen, P., Lu, D., & Hao, W. (2018). Single cell whole genome sequencing reveals that NFKB1 mutation affects radiotherapy sensitivity in cervical cancer. Oncotarget, 9(7), 7332.