Creative Biolabs

Mouse Anti-NFKB1 Monoclonal Antibody (2G1E3), Unconjugated

[CAT#: NAB20101961CR]

Mouse Monoclonal (2G1E3) to NFKB1

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IF; IHC; WB; ELISA

Datasheet MSDS Request COA

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Bulk Quote
Description
NFkB is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFkB is activated by various intra- and extracellular stimuli such as cytokines, oxidant free radicals, ultraviolet irradiation, and bacterial or viral products. NFkB is a family of transcription factors that consists of homo- and heterodimers of NFkB1/p50 and RelA/p65 subunits, and controls a variety of cellular events including development and immune responses. All members share a conserved amino terminus domain that includes dimerization, nuclear localization, and DNA binding regions, and a carboxy terminal transactivation domain. Serines 529 and 536 in the transactivation domain of RelA/p65 are phosphorylated in response to several stimuli including phorbol ester, IL1 alpha and TNF alpha as mediated by IkB kinase and p38 MAPK. Phosphorylation of serines 529 and 536 is critical for RelA/p65 transcriptional activity.
Expression Host
Mammalian cells
Immunogen
NFKB1 fusion protein Ag5832
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2a
Clone Number
2G1E3
Applications
IF; IHC; WB; ELISA
Application Notes
IF : 1:20-1:200; IHC : 1:20-1:200; WB : 1:500-1:1000
Relevant Diseases
Neurological Disorders
Research Areas
Neural Signal Transduction
Conjugation
Unconjugated
Form
Liquid
Formulation
PBS, 0.1% sodium azide and 50% glycerol pH 7.3.
Preservatives
Yes
Concentration
1000 μg/ml
Purification
Antigen affinity purification
Purity
>95%, as determined by SDS-PAGE
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store at -20°C. Stable for one year after shipment.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
NFKB1
Official Name
NFKB1
Full Name
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Alternative Names
DNA binding factor KBF1;
DNA binding factor KBF1 EBP1;
DNA-binding factor KBF1;
EBP 1;
EBP-1;
EBP1;
KBF1;
Gene ID
4790(Human); 18033(Mouse); 81736(Rat)
Uniprot ID
P19838(Human); P25799(Mouse); Q63369(Rat)
1. Wang, M., Wang, Z., Zhu, X., Guan, S., & Liu, Z. (2019). NFKB1-miR-612-FAIM2 pathway regulates tumorigenesis in neurofibromatosis type 1. In Vitro Cellular & Developmental Biology-Animal, 55(7), 491-500. 2. Yang, D., Zhang, W., Liang, J., Ma, K., Chen, P., Lu, D., & Hao, W. (2018). Single cell whole genome sequencing reveals that NFKB1 mutation affects radiotherapy sensitivity in cervical cancer. Oncotarget, 9(7), 7332.
For Research Use Only. Not For Clinical Use.
Send Inquiry Send Inquiry
Inquiry Basket
compare

Go to compare