Mouse Anti-NFkB p50 Monoclonal Antibody (CBP2557)

Product Overview

Description

Mouse anti-human NFkB p50 antibody recognizes nuclear factor NF-kappa-B p50 subunit, also known as DNA binding factor KBF1, NF-kappabeta, nuclear factor NF-kappa-B p50 subunit or nuclear factor κ-B DNA binding subunit. NFKB1 encodes a 105 kD protein, which can be co-translationally processed by 26S proteasome to produce a 50 kD protein. 105 kD protein is a specific transcription inhibitor of Rel protein, and 50 kD protein is the DNA binding subunit of the NF-κB (NFKB) protein complex. NFKB is a transcriptional regulator that can be activated by various intracellular and extracellular stimuli, such as cytokines, free radicals, ultraviolet radiation, and bacterial or viral products. The activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a variety of biological functions. Inappropriate activation of NFKB is associated with many inflammatory diseases, and continuous inhibition of NFKB can lead to inappropriate immune cell development or cell growth delay. For NFKB1, two transcript variants encoding different isoforms were found.

Immunogen

Recombinant human NFkB p50 (aa 1-200).

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2557

Applications

Application Notes

WB: 1/1000

Relevant Diseases

Alzheimer's Disease; Neurodegenerative Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 1% BSA, 0.09% Sodium Azide

Preservatives

YES

Purification

Protein G

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

NFKB1

Official Name

NFKB1

Full Name

Nuclear Factor Kappa B Subunit 1

Alternative Names

Nuclear Factor Kappa B Subunit 1; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 1; DNA-Binding Factor KBF1; EBP-1; Nuclear Factor Kappa-B DNA Binding Subunit; Nuclear Factor NF-Kappa-B P105 Subunit; Nuclear Factor NF-Kappa-B P50 Subunit; NF-Kappabeta; NF-Kappa-B; NF-KappaB;