mTOR shRNA Plasmid Expression Vector Set

Name: mTOR shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY341
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY341]

Target:: mTOR

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Product Overview

Description

A comprehensive and powerful tool for the targeted knockdown of the mechanistic Target of Rapamycin (mTOR) gene. The set includes three sequence-verified shRNA plasmid vectors, each designed to target a different region of the human mTOR mRNA to ensure potent and reliable gene silencing. A non-targeting scrambled shRNA plasmid is also included to serve as an experimental negative control. As a central regulator of cell growth, proliferation, and metabolism, mTOR is one of the most critical signaling nodes in cellular biology. This ready-to-transfect kit is an essential tool for researchers investigating the mTOR pathway's role in cancer, neurodevelopmental disorders like autism and epilepsy, autophagy, and the aging process.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

mTOR

Full Name

Serine/Threonine-Protein Kinase mTOR

Alternative Names

FRAP1; RAFT1; Mechanistic target of rapamycin

Gene ID

2475

Uniprot ID

P42345

Target Overview

The mechanistic target of rapamycin (mTOR) is a crucial serine/threonine kinase that serves as a central regulator of cell metabolism, growth, proliferation, and survival. It integrates signals from various upstream pathways, including nutrients, energy levels, and growth factors, to control key cellular activities like protein synthesis and autophagy. mTOR forms the catalytic core of two distinct protein complexes, mTORC1 and mTORC2, each with different downstream targets and functions. Because its signaling pathway is frequently hyperactive in many human diseases, most notably cancer, mTOR is a major therapeutic target.

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