Neuroligin shRNA Plasmid Expression Vector Set

Name: Neuroligin shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY356
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY356]

Target:: Neuroligin

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Product Overview

Description

An effective kit for the specific knockdown of the Neuroligin (e.g., NLGN3) gene family, the postsynaptic binding partners of Neurexins. The set provides three distinct shRNA plasmid vectors targeting a specific Neuroligin isoform, along with a scrambled shRNA plasmid as a negative control. It enables research into how Neuroligin dysfunction, linked to autism, disrupts synaptic balance.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

Neuroligin

Full Name

Neurexin-1

Alternative Names

NRXN1

Gene ID

9378

Uniprot ID

Q9ULB1

Target Overview

Neurexins are a family of presynaptic cell adhesion molecules (encoded by the NRXN1, NRXN2, and NRXN3 genes) that are essential for the proper formation and function of synapses in the brain. They act as key organizers at the synapse by binding to a variety of postsynaptic partners, most notably Neuroligins, to form a trans-synaptic bridge. This interaction is critical for specifying synaptic properties and ensuring correct neurotransmission. Due to their fundamental role in building and maintaining neural circuits, genetic disruptions of Neurexin genes are strongly associated with a range of neurodevelopmental disorders, including Autism Spectrum Disorder (ASD) and schizophrenia.

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