Mouse Anti-Human LAMA5 Monoclonal Antibody (CBP1512)

Description

The mouse anti-human Laminin Alpha 5 antibody recognizes Laminin alpha 5 chain, also known as Laminin-10 subunit α, Laminin-11 subunit α or Laminin-15 subunit α. Laminin is a complex glycoprotein composed of three polypeptide chain complexes. Laminin α5 is expressed in the heart, lung, kidney, skeletal muscle, pancreas, retina and placenta, and almost not expressed in the brain and liver.

Immunogen

Purified human laminin.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP1512

Applications

ELISA; IF; IP

Research Areas

Growth and Development

Conjugation

Unconjugated

Form

Ascites - liquid

Formulation

Ascites-liquid
0.09% Sodium Azide

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Target

Laminin 5

Official Name

LAMA5

Full Name

Laminin subunit alpha-5

Alternative Names

LAMA5; Laminin; alpha 5; laminin subunit alpha 5

Gene ID

3911(Human)

Uniprot ID

O15230(Human)

1. Engvall, E. et al. (1986) Mapping of domains in human laminin using monoclonal antibodies: localization of the neurite-promoting site. 2. Engvall, E. et al. (1990) Distribution and isolation of four laminin variants; tissue restricted distribution of heterotrimers assembled from five different subunits. 3. Ido, H. et al. (2006) Probing the integrin-binding site within the globular domain of laminin-511 with the function-blocking monoclonal antibody 4C7. 4. Chang, C. et al. (2015) A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells. 5. Zamurs, L. et al. (2013) Chain-specific antibodies for laminin-511. 6. Tiger, C.F. et al. (1997) Presence of laminin alpha5 chain and lack of laminin alpha1 chain during human muscle development and in muscular dystrophies. 7. Pouliot, N. & Kusuma, N. (2013) Laminin-511: a multi-functional adhesion protein regulating cell migration, tumor invasion and metastasis. 8. Schaff, M. et al. (2013) Integrin α6β1 is the main receptor for vascular laminins and plays a role in platelet adhesion, activation, and arterial thrombosis. 9. Vuoristo, S. et al. (2013) A novel feeder-free culture system for human pluripotent stem cell culture and induced pluripotent stem cell derivation. 10. Wondimu, Z. et al. (2013) A novel monoclonal antibody to human laminin α5 chain strongly inhibits integrin-mediated cell adhesion and migration on laminins 511 and 521. 11. Breitkreutz, D. et al. (2013) Skin basement membrane: the foundation of epidermal integrity--BM functions and diverse roles of bridging molecules nidogen and perlecan.