Human Anti-GAPDH Monoclonal Antibody (CBP1947)

Product Overview

Description

Human anti-GAPDH antibody, clone AbD22549_hIgG1 recognizes human glyceraldehyde 3-phosphate dehydrogenase (GAPDH), a 335 amino acid multifunctional protein. The main function of GAPDH is to catalyze the reversible oxidative phosphorylation of glyceraldehyde 3-phosphate together with inorganic phosphate and nicotinamide adenine dinucleotide (NAD). It is the main glycolytic enzyme in the cytoplasm and is also involved in many intracellular processes, including membrane fusion, microtubule bundling, phosphotransferase, DNA replication and DNA repair. It has also been shown to translocate to the nucleus under multiple stressors, most of which are related to oxidative stress, thereby mediating cell death.
It has been shown that GAPDH binds to several proteins responsible for neurodegenerative diseases, such as amyloid precursor protein and huntingtin.

Immunogen

Recombinant human GAPDH

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Human

Isotype

IgG1

Clone Number

CBP1947

Applications

WB; IP

Application Notes

WB (1/50-1/800)

Relevant Diseases

Huntington's Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS; 0.01% Thiomersal

Preservatives

Yes

Concentration

0.5 mg/ml

Purification

Purified IgG prepared by affinity chromatography on Protein A.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

GAPDH

Official Name

GAPDH

Full Name

Glyceraldehyde-3-Phosphate Dehydrogenase

Alternative Names

Glyceraldehyde-3-Phosphate Dehydrogenase; Peptidyl-Cysteine S-Nitrosylase GAPDH; EC 1.2.1.12; GAPD; Epididymis Secretory Sperm Binding Protein Li 162eP; Oct1 Coactivator In S Phase; 38 Kd Component; Aging-Associated Gene 9 Protein;