Rat Anti-Mouse Nurr1 Monoclonal Antibody (CBP2171)

Product Overview

Description

NR4A2, also known as Nurr1, is a member of the orphan nuclear receptor family 4 subgroup A (NR4A) superfamily. NR4A2 is a transcription factor that regulates expression of the key enzyme required for the synthesis of dopamine and is essential in the differentiation, maturation, and survival of dopaminergic neurons. NR4A2 is involved in the regulation of several neuronal events, including axon outgrowth, neuronal patterning, and terminal differentiation. Mutation or dysregulation of NR4A2 have been linked to brain diseases such as Alzheimer's disease, Schizophrenia, and Parkinson's disease. NR4A2 is pivotal for the function of regulatory T cells and has been found to play regulatory roles in inflammatory arthritis. NR4A2 is expressed at elevated levels in inflamed joint tissues from patients with rheumatoid arthritis, osteoarthritis, and psoriatic arthritis.

Immunogen

Partial mouse NR4A2 recombinant protein (1-200 a.a.) expressed in E. coli.

Species Reactivity

Mouse

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2b, κ

Clone Number

CBP2171

Applications

Application Notes

WB (0.5-2.5 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Nurr1

Official Name

NR4A2

Full Name

Nuclear receptor related 1 protein

Alternative Names

Nuclear receptor subfamily 4 group A member 2; NUR-related factor 1 (Nurr1); Orphan nuclear receptor NURR1

Gene ID

4929(Human); 54278(Mouse); 54278(Rat)

Uniprot ID

P43354(Human); Q07917(Rat)

References

1. Liu H, et al. 2015. Neurosci. Lett. 598:85.
2. Navone ND, et al. 2014. J. Neuroimmunol. 272:99.
3. Chen S, et al. 2013. J. Mol. Neurosci. 51:719.
4. Han Y, et al. 2013. Cancer 119:3436.
5. Sekiya T, et al. 2011. Nat. Commun. 2:269.
6. Aherne CM, et al. 2009. Mol. Immunol. 46:3345.

Publications