Mouse Anti-PAK1 Monoclonal Antibody (CBP2262)

Product Overview

Description

PAK1 is a ubiquitously expressed protein that belongs to the group I PAK family of serine/threonine kinases, which are important mediators that link the Rho family GTPase signaling to cytoskeleton remodeling. PAK1 activation has been shown to play a role in tumorgenesis, actin dynamics, cell cycle progression, cell motility, and angiogenesis. The PAK family of kinases is affected in several brain diseases, including neurofibromatosis model of autism, Alzheimer's disease, Fragile X syndrome, and schizophrenia1. Recent studies using electrophysiological recordings of hippocampal CA1 synaptic currents suggest that PAK1 plays a role in inhibitory synaptic transmission, where knocking out PAK1 affects the excitatory/inhibitory balance in the hippocampus, and may lead to dysregulation of synaptic strength.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP2262

Applications

Application Notes

WB (0.1-1.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

PAK1

Official Name

PAK1

Full Name

Serine/threonine-protein kinase PAK 1

Alternative Names

PAK1; PAKalpha; p21 (RAC1) activated kinase 1; IDDMSSD

Gene ID

5058 (Human); 18479 (Mouse)

Uniprot ID

Q13153 (Human); Q88643 (Mouse)

References

1. Kreis P, et al. 2009. Cell Signal. 21(3):384
2. Nikolic M. 2008. Mol Neurobiol. 37(2-3): 187
3. Salminen A, et al. 2008. Biochem Biophys Res Commun. 371(4):587

Publications