Anti-PAK1 Monoclonal Antibody (CBP3725)

Product Overview

Description

PAK1 is a ubiquitously expressed protein that belongs to the group I PAK family of serine/threonine kinases. PAK1 activation has been shown to play a role in tumorgenesis, actin dynamics, cell cycle progression, cell motility, and angiogenesis. The PAK family of kinases is affected in several brain diseases, including neurofibromatosis model of autism, Alzheimer's Disease, Fragile X syndrome and schizophrenia1. Recently studies suggest that PAK1 plays a role in inhibitory synaptic transmission.

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a, κ

Clone Number

CBP3725

Applications

WB; IHC-P

Application Notes

WB (0.1-1.0 µg/mL); IHC-P (0.2-2.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

PAK1

Official Name

PAK1

Full Name

Alpha-PAK

Alternative Names

Alpha PAK;
Alpha-PAK;
MGC130000;
MGC130001;
p21 activated kinase 1;
p21 protein (Cdc42/Rac) activated kinase 1;
p21-activated kinase 1;
p21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related);
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog; yeast);
p65 PAK;
p65-PAK;
P68-PAK;
PAK alpha;

Gene ID

5058(Human); 18479(Mouse); 29431(Rat)

Uniprot ID

Q13153(Human); O88643(Mouse); P35465(Rat)

References

1. Xia S, et al. 2018. Small GTPases. 9(4):322
2. Kreis P, et al. 2009. Cell Signal. 21(3):384
3. Nikolic M. 2008. Mol Neurobiol. 37(2-3): 187
4. Salminen A, et al. 2008. Biochem Biophys Res Commun. 371(4):587

Publications