Mouse Anti-Human LRRK2 Monoclonal Antibody (CBP2345)

Product Overview

Description

Leucine-rich repeat kinase 2 (LRRK2), is a member of the leucine-rich repeat kinase family. This protein also functions as a GTPase. Proteins with leucine-rich regions play a role in protein-protein interactions and mediate assembly of the cell's structural framework (cytoskeleton). Mutations in LRRK2 genes have been associated with late-onset Parkinson's disease.

Immunogen

This monoclonal antibody was raised against a peptide immunogen comprising amino acids 2069-2087 of the LRRK2 protein in mice that did not express endogenous LRRK2 protein.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2345

Applications

IHC-P; ELISA

Application Notes

IHC-P (f 25 µg/mL); ELISA (1.0-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

1.0 mg/ml

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

LRRK2

Official Name

LRRK2

Full Name

Leucine-rich repeat kinase 2

Alternative Names

LRRK2; AURA17; DARDARIN; PARK8; RIPK7; ROCO2; leucine-rich repeat kinase 2; leucine rich repeat kinase 2

Gene ID

120892(Human); 66725(Mouse); 300160(Rat)

Uniprot ID

Q5S007(Human); Q5S006(Mouse)

References

1. Paisán-Ruíz C, et al. 2004. Neuron. 44(4):595-600.
2. Alegre-Abarrategui J, et al. 2009. Hum. Mol. Genet. 18(21):4022-34.
3. Gómez-Suaga P, et al. 2012. Hum. Mol. Genet. 21(3):511-25.
4. Orenstein SJ, et al. 2013. Nat. Neurosci. 16(4):394-406.
5. Cherra SJ, et al. 2013. Am. J. Pathol. 182(2):474-84.

Publications