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Creative Biolabs

Mouse Anti-Rat GluN2A/NMDAR2A Monoclonal Antibody (CBP2361)

[CAT#: NAB2010363LS]

Anti-GluN2A/NMDAR2A Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Rat
Applications:
WB

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Product Overview

Description

Glutamate activated Ion channels that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDA receptor plays an essential role in the induction of LTP in the CA1 and dentate areas of the hippocampus as the specific NMDA antagonist, APV blocks LTP in these areas. This receptor has also been linked to neuronal development and it has been implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.

Immunogen

This monoclonal antibody was raised against a fusion protein corresponding to amino acids 75-325 (extracellular, N-terminus) of rat GluN2A/NR2A glutamate receptor protein.

Species Reactivity

Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP2361

Applications

WB

Application Notes

WB (10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated
Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

1.0 mg/ml

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.
Target

Target

GRIN2A

Official Name

GRIN2A

Full Name

Glutamate [NMDA] receptor subunit epsilon-1

Alternative Names

GRIN2A; EPND; FESD; GluN2A; LKS; NMDAR2A; NR2A; glutamate ionotropic receptor NMDA type subunit 2A

Gene ID

2903(Human); 14811(Mouse); 24409(Rat)

Uniprot ID

Q12879(Human); P35436(Mouse); Q00959(Rat)
Publications

Publications (0)

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For Research Use Only. Not For Clinical Use.
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