Mouse Anti-TGFBI Monoclonal Antibody (CBP2595)

Description

TGFBI is an adhesion protein which may play an important role in cell-collagen interactions. In cartilage, it may be involved in endochondral bone formation. TGFBI is an extracellular matrix adaptor protein, it has been reported to be differentially expressed in transformed tissues. TGFBI is a predictive factor of the response to chemotherapy, and suggest the use of TGFBI-derived peptides as possible therapeutic adjuvants for the enhancement of responses to chemotherapy.(PMID:20509890) Defects in TGFBI are the cause of epithelial basement membrane corneal dystrophy (EBMD). Defects in TGFBI are the cause of corneal dystrophy Groenouw type 1 (CDGG1). Defects in TGFBI are the cause of corneal dystrophy lattice type 1 (CDL1). Defects in TGFBI are a cause of corneal dystrophy Thiel-Behnke type (CDTB). Defects in TGFBI are the cause of Reis-Buecklers corneal dystrophy (CDRB). Defects in TGFBI are the cause of lattice corneal dystrophy type 3A (CDL3A). Defects in TGFBI are the cause of Avellino corneal dystrophy (ACD).

Expression Host

Mammalian cells

Immunogen

TGFBI / BIGH3 fusion protein Ag0241

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP2595

Applications

IHC; IP; WB; ELISA

Application Notes

IHC : 1:20-1:200; IP : 0.5-4.0 ug; WB : 1:500-1:1000

Research Areas

Growth and Development

Conjugation

Unconjugated

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

393 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

TGFBI

Official Name

TGFBI

Full Name

Transforming growth factor, beta-induced, 68kDa

Alternative Names

Beta ig h3; BIGH3; CDB1; CDG2; CDGG1; CSD; CSD1; CSD2; CSD3; EBMD; Kerato epithelin; LCD1; RGD CAP; TGFBI

Gene ID

7045(Human); 21810(Mouse); 116487(Rat)

Uniprot ID

Q15582(Human); P82198(Mouse)

1. Ge, H., Cao, W., Leng, F., Chen, W., Liu, P., & Chen, W. (2008). Modified BIGH3 with an RGDRGD motif promotes human corneal epithelial cell adhesion and migration in vitro. Current eye research, 33(3), 215-223. 2. Annis, D. S., Ma, H., Balas, D. M., Kumfer, K. T., Sandbo, N., Potts, G. K.,... & Mosher, D. F. (2015). Absence of vitamin K-dependent γ-carboxylation in human periostin extracted from fibrotic lung or secreted from a cell line engineered to optimize γ-carboxylation. PloS one, 10(8), e0135374. 3. Pan, T., Lin, S. C., Yu, K. J., Yu, G., Song, J. H., Lewis, V. O.,... & Jonasch, E. (2018). BIGH3 promotes osteolytic lesions in renal cell carcinoma bone metastasis by inhibiting osteoblast differentiation. Neoplasia, 20(1), 32-43.