Mouse Anti-ALK Monoclonal Antibody (CBP2666)

Product Overview

Description

ALK is a receptor tyrosine kinase (RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM (Nucleophosmin)-ALK oncogenic fusion protein, resulting from the (2; 5)(p23; q35) translocation that is frequently associated with anaplastic large-cell lymphoma (ALCL). The EML4 (echinoderm microtubule-associated protein-like 4)-ALK fusion protein have been described in non-small-cell lung cancer (NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC.

Expression Host

Mammalian cells

Immunogen

ALK/CD246 fusion protein Ag21493

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP2666

Applications

IHC; WB; ELISA

Application Notes

IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Metabolism

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1600 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

ALK

Official Name

ALK

Full Name

Anaplastic lymphoma receptor tyrosine kinase

Alternative Names

Alk;
ALK tyrosine kinase receptor;
ALK/EML4 fusion gene; included;
ALK/NPM1 fusion gene; included;
ALK_HUMAN;
anaplastic lymphoma kinase (Ki-1);
Anaplastic lymphoma kinase;
Anaplastic lymphoma kinase Ki1;
anaplastic lymphoma receptor tyrosine kinase;
CD 246;