Mouse Anti-NAMPT Monoclonal Antibody (CBP2759)

Product Overview

Description

Nicotinamide phosphoribosyltransferase(NAMPT) has two usual synonyms termed Visfatin and PBEF. Its primary role is to catalyze the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD, which is the rate limiting component in the mammalian NAD biosynthesis pathway. NAMPT is localized in cytoplasm and expressed in large amounts in bone marrow, liver tissue, and muscle tissues. NAMPT inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. NAMPT levels are altered in plasma of patients with type 2 diabetes mellitus (T2DM), and it is now evidenced that NAMPT may plays a role in lipid metabolism.

Expression Host

Mammalian cells

Immunogen

NAMPT/PBEF fusion protein Ag2434

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP2759

Applications

IF; IHC; WB; ELISA

Application Notes

IF : 1:20-1:200; IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Metabolism

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Visfatin

Official Name

NAMPT

Full Name

Nicotinamide phosphoribosyltransferase

Alternative Names

1110035O14Rik; NAmPRTase; NAMPT; PBEF; PBEF1; Pre B cell enhancing factor; VF; VISFATIN

Gene ID

10135(Human); 59027(Mouse); 297508(Rat)

Uniprot ID

P43490(Human); Q99KQ4(Mouse); Q80Z29(Rat)

References

1. Pan, J. H., Zhou, H., Zhu, S. B., Huang, J. L., Zhao, X. X., Ding, H.,... & Pan, Y. L. (2019). Nicotinamide phosphoribosyl transferase regulates cell growth via the Sirt1/P53 signaling pathway and is a prognosis marker in colorectal cancer. Journal of Cellular Physiology, 234(4), 4385-4395.

Publications