Mouse Anti-FYN Monoclonal Antibody (CBP2812)

Product Overview

Description

FYN belongs to the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. FYN is implicated in the control of cell growth. It plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. FYN is required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. FYN blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC.

Expression Host

Mammalian cells

Immunogen

FYN fusion protein Ag11127

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2812

Applications

IHC; WB; ELISA

Application Notes

IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Neuron

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Fyn

Official Name

FYN

Full Name

FYN oncogene related to SRC, FGR, YES

Alternative Names

FYN; p59 Fyn; Proto oncogene c Fyn; Proto oncogene Syn; SLK; Src like kinase; SYN; Tyrosine protein kinase Fyn

Gene ID

2534(Human); 14360(Mouse); 25150(Rat)

Uniprot ID

P06241(Human); P39688(Mouse); Q62844(Rat)

References

1. Luo, X., Li, Y., Yang, P., Chen, Y., Wei, L., Yu, T.,... & Chen, Y. (2020). Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function. EBioMedicine, 56, 102797. 2. Niu, Q., Sun, W., Chen, Q., Long, Y., Cao, W., Wen, S.,... & Shi, H. (2020). Protective Effects of Ischemic Postconditioning on Livers in Rats with Limb Ischemia-Reperfusion via Glycogen Synthase Kinase 3 beta (GSK-3β)/Fyn/Nuclear Receptor-Erythroid-2-Related Factor (Nrf2) Pathway. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 26, e923049-1. 3. Yuan, H., Zhou, W., Yang, Y., Xue, L., Liu, L., & Song, Y. (2018). ISG15 promotes esophageal squamous cell carcinoma tumorigenesis via c-MET/Fyn/β-catenin signaling pathway. Experimental cell research, 367(1), 47-55.

Publications