Mouse Anti-GSK3B Monoclonal Antibody (CBP2972)

Product Overview

Description

Glycogen synthase kinase-3 (GSK3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase.GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation.In skeletal muscle, it contributes to INS regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Researches showed that the crystal structure of human GSK3B, expressed in insect cells, at 2.8-angstrom resolution.

Expression Host

Mammalian cells

Immunogen

Peptide

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2972

Applications

IF; IHC; WB; ELISA

Application Notes

IF : 1:20-1:200; IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Metabolism

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

2240 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

GSK3 Beta

Official Name

GSK3B

Full Name

Glycogen synthase kinase 3 beta

Alternative Names

Glycogen Synthase Kinase 3 Beta;
Glycogen synthase kinase-3 beta;
GSK 3 beta;
GSK-3 beta;
GSK3B;
GSK3B_HUMAN;
GSK3beta isoform;
Serine/threonine-protein kinase GSK3B;

Gene ID

2932(Human); 56637(Mouse)

Uniprot ID

P49841(Human); Q9WV60(Mouse)

References

1. Li, W., Wang, D., Sun, X., Zhang, Y., Wang, L., & Suo, J. (2019). ADAM17 promotes lymph node metastasis in gastric cancer via activation of the Notch and Wnt signaling pathways. International journal of molecular medicine, 43(2), 914-926. 2. Xu, L., Xing, Q., Huang, T., Zhou, J., Liu, T., Cui, Y.,... & Yang, G. L. (2019). HDAC1 silence promotes neuroprotective effects of human umbilical cord-derived mesenchymal stem cells in a mouse model of traumatic brain injury via PI3K/AKT pathway. Frontiers in Cellular Neuroscience, 12, 498.

Publications