Anti-Ataxin-2 Monoclonal Antibody (CBP3732)
[CAT#: NAB201292LS]
Anti-Ataxin-2 Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human; Rat
- Applications:
- WB; IHC-P
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Ataxin-2 is a polyglutamine protein involved in a variety of biological processes, including regulating mRNA translation. Ataxin-2 contains two domains, Sm1 and Sm2, which are related to RNA splicing and protein interaction. In the brain, ataxia 2 is expressed in the hypothalamus, which is the brain area responsible for controlling energy balance and metabolic homeostasis. Ataxin-2 mutations are associated with the development of type 2 spinocerebellar ataxia. Ataxin-2 mutant protein with medium-length polyglutamine amplification (27-33 polyQ) can modify the toxicity of TDP-43 and increase the risk of amyotrophic lateral sclerosis.
Immunogen
Human ataxin-2 recombinant protein
Species Reactivity
Human; Rat
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2b, κ
Clone Number
CBP3732
Applications
WB; IHC-P
Application Notes
IHC-P (1-10 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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