Mouse Anti-Human CD46 Monoclonal Antibody (CBP3849)

[CAT#: NAB2012372LS]

Anti-CD46 Monoclonal Antibody [FITC]

Host Species:: Mouse

Species Reactivity:: Human

Applications:: FC

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Product Overview

Description

CD46 is a transmembrane protein also known as complement membrane cofactor protein, MCP, and measles virus receptor.CD46 binds complement components C3b and C4b and has also been reported to play a role in T cell regulation. In addition to the complement components, CD46 has been shown to interact with moesin, c-Src, tetraspanin 4, c-Yes, and integrin β1. CD46 is also known to be a cellular receptor for human measles virus and human herpes virus-6. Defects in CD46 have been associated with hemolytic-uremic syndrome.

Immunogen

HPB-ALL T cell line

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP3849

Applications

Application Notes

FCM (5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Alexa Fluor 594; Alexa Fluor 488; Alexa Fluor 498; Alexa Fluor 647; Alexa Fluor 700; APC; APC/Cyanine 7; APC/Fire 750; Biotin; Brilliant Violet 421; Brilliant Violet 510; Brilliant Violet 570; Brilliant Violet 570; Brilliant Violet 605; Brilliant Violet 650; Brilliant Violet 711; Brilliant Violet 750; Brilliant Violet 785; FITC; HRP; PE; Pacific Blue; PE/Cyanine 5; PE/Cyanine 7; PerCP; Spark YG 570

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.

Concentration

1.0 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD46

Official Name

CD46

Full Name

CD46 complement regulatory protein

Alternative Names

CD46; AHUS2; MCP; MIC10; TLX; TRA2.10; CD46 molecule

Gene ID

4719 (Human); 17221 (Mouse)

Uniprot ID

P15529 (Human); O88174 (Mouse)

References

1. Cardone J, et al. 2010. Nat. Immunol. 11:862.
2. Dorig RE, et al. 1993. Cell 75:295.
3. Kemper C, et al. 2003. Nature 421:388.
4. Frecha C, et al. 2011. J. Virol. 85:5975.
5. Adams EM, et al. 1991. J. Immunol. 147:3005.

Publications