Anti-CD45RB Monoclonal Antibody (CBP3850)

[CAT#: NAB2012373LS]

Anti-CD45RB Monoclonal Antibody [FITC]

Host Species:: Mouse

Species Reactivity:: Human; African green monkey; Baboon; Cynomolgus; Rhesus

Applications:: FC

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Product Overview

Description

CD45RB is a 180-240 kD single chain type I membrane glycoprotein. CD45RB is an exon 5 splice variant of the tyrosine phosphatase CD45. The CD45RB isoform is expressed on thymocytes, T cell subsets, B cells, monocytes/macrophages, granulocytes, and dendritic cells. CD45RB enhances both T cell receptor and B cell receptor signaling mediated activation. CD45 and its isoforms non-covalently associate with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes.

Immunogen

Human thymocytes and T lymphocytes

Species Reactivity

Human; African green monkey; Baboon; Cynomolgus; Rhesus

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP3850

Applications

Application Notes

FCM (5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.

Concentration

1.0 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD45

Official Name

PTPRC

Full Name

Protein tyrosine phosphatase, receptor type, C

Alternative Names

PTPRC; B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200; protein tyrosine phosphatase; receptor type C; protein tyrosine phosphatase receptor type C

Gene ID

5788 (Human); 19264 (Mouse)

Uniprot ID

P08575 (Human); P08575 (Mouse)

References

1. Lee KM, et al. 2014. Cell Transplant. 23:51.
2. Kamanaka M, et al. 2011. J. Exp. Med. 208:1027.
3. Gagliani N, et al. 2011. PLoS One 6(12):e28434.
4. Ten Hove T, et al. 2004. J. Leuko. Biol. 75:1010.
5. Ogilvy S, et al. 2003. J. Immunol. 171:1792.

Publications