Anti-ADAM10 Monoclonal Antibody (CBP3966)

Product Overview

Description

CD156c, also known as integrin and metalloprotease domain-containing protein 10 (ADAM10), is a 748 amino acid type I membrane glycoprotein that is commonly expressed on most cell types. It is composed of multiple functional domains, including N-terminal prodomain, catalytic domain, cysteine-rich domain, transmembrane domain and cytoplasmic domain. It is secreted as a precursor protein and becomes the activated/mature form by removing the ADAM10 prodomain by proprotein convertase 7 and furin. ADAM10 is used as a metalloprotease and can cleave multiple molecules, including Notch, TNF-α precursor, amyloid precursor protein, myelin basic protein and type IV collagen. It mediates the release of several cell adhesion molecules, such as vascular endothelial cadherin or L-selectin, to regulate endothelial permeability and leukocyte migration. The imbalance of ADAM activity may contribute to the pathogenesis of vascular diseases.

Species Reactivity

Human; African green monkey; Baboon; Cynomolgus; Rhesus

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP3966

Applications

Application Notes

FCM (5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

ADAM10

Official Name

ADAM10

Full Name

ADAM metallopeptidase domain 10

Alternative Names

A disintegrin and metalloprotease domain 10;
A disintegrin and metalloproteinase domain 10;
AD 10;
AD10;
AD18;
ADA10_HUMAN;
ADAM 10;
ADAM metallopeptidase domain 10;
ADAM10;
CD 156c;
CD156c;
CD156c antigen;