Mouse Anti-Histone-h4-trimethyl-lys-19 Monoclonal Antibody (CBP4311)

[CAT#: NAB210184LS]

Anti-Histone-h4-trimethyl-lys-19 Monoclonal Antibody [HRP]

Host Species:: Mouse

Species Reactivity:: Human; Rat

Applications:: IHC-P

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Request Pricing

Inquiry

Product Overview

Description

Histone proteins are classified into core histones (H2A, H2B, H3, H4) and linker histones (H1, H5). Core histones form an octamer, which contains two H2A-H2B dimers and one H3-H4 tetramer. Core histones are predominantly globular except for the unstructured N-terminal tails. Posttranslational modifications, such as acetylation, methylation, phosphorylation, ubiquitination, SUMOylation and ADP-ribosylation occur in histone tails.

Immunogen

This monoclonal antibody was raised against a synthetic peptide conjugated to KLH containing trimethylated lysine 20 of human Histone H4

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP4311

Applications

IHC-P

Application Notes

IHC-P ( 5.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

HRP

Product Properties

Form

Liquid

Formulation

This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Histone-h4-trimethyl-lys-19

Official Name

H4F3

Full Name

Histone H4

Alternative Names

Histone H4; H4F3

Gene ID

4780

Uniprot ID

P62805

References

1. Chen HM, et al. 2015. Epigenetics and Dermatology. 409:441.
2. Wang Z, et al. 2008. Nat. Genet. 40:897.
3. Beck DB, et al. 2012. Genes Dev. 26:325.

Publications