Mouse Anti-Methyl-CpG Binding Protein 2 (CBP6707)

Product Overview

Description

Methyl-CpG binding protein 2 (MeCP2) is widely expressed in tissues, especially in neurons. It is a nuclear protein that has been found to bind to methylated cytosines on CpG islands in DNA, but may also bind to hydroxymethylcytosine residues (1-3). Methyl and hydroxymethyl cytosine are usually found in DNA regions that regulate the expression of specific genes, and MeCP2 is considered a gene regulator, although it may have other functions. The MeCP2 protein contains a methyl-CpG binding domain and two AT hook domains, which are highly basic peptides that bind AT-rich DNA sequences. The MeCP2 gene MECP2 is located on the X chromosome. Loss-of-function mutations of this gene can cause Rett syndrome, which is a relatively rare neurodevelopmental and autistic disease that occurs almost exclusively in women, because similar mutations in MECP2 are almost always in men. Is fatal. 3).

Immunogen

Recombinant full-length human MeCP2 expressed and purified in E. coli.

Species Reactivity

Human; Rat; Mouse; Dog; Cow; Horse; Monkey

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP6707

Applications

WB; IF; IHC

Application Notes

WB: 1:5,000-10,000 ICC/IF or IHC: 1:1,000-5,000

Product Properties

Form

Liquid

Formulation

50% PBS, 50% glycerol

Preservatives

5mM NaN3

Concentration

1 mg/ml

Shipping

Gel Pack

Storage

Stable at 4°C for one year, for longer term store at -20°C

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

MECP2

Official Name

MECP2

Full Name

Methyl-CpG Binding Protein 2

Alternative Names

Methyl-CpG Binding Protein 2; MeCp-2 Protein; Methyl CpG Binding Protein 2 (Rett Syndrome); Testis Tissue Sperm-Binding Protein Li 41a; Mental Retardation; X-Linked 16; Mental Retardation; X-Linked 79; Methyl CpG Binding Protein 2; Methyl-CpG-Binding Protein 2; Rett Syndrome; AUTSX3;