Rabbit Anti-CAMK2A/CAMK2B (CBP749)

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to Human CaMKII alpha + CaMKII beta (phospho T286) aa 250-350.

Species Reactivity

Mouse; Rat; Human

Clonality

Monoclonal

Host Species

Rabbit

Isotype

IgG

Clone Number

CBP749

Applications

WB

Application Notes

WB (1:1000-100000)

Research Areas

Neurotransmission

Pathways

Calcium Signaling

Marker

Calcium Channels

Conjugation

Unconjugated

Formulation

pH: 7.20
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 40% Glycerol, 9.85% Tris glycine, 50% Tissue culture supernatant

Purification

Tissue culture supernatant

Purity

>95%

Shipping

Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

Storage

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Notes: avoid repeated freeze-thaw cycles.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CaMKII Alpha; CaMKII Beta

Official Name

CAMK2A; CAMK2B

Full Name

Calcium/calmodulin-dependent protein kinase type II subunit alpha

Alternative Names

Calcium/calmodulin-dependent protein kinase type II subunit α (CAMKIIα); also known as Ca2+/calmodulin-dependent protein kinase IIα; is a subunit of CamKII; CamKII is a protein kinase in humans (even though Protein phosphorylation enzyme); by the CAMK2A gene.

The product of the CAMK2A gene is an enzyme belonging to the serine/threonine-specific protein kinase family and the Ca2+/calmodulin-dependent protein kinase II subfamily. Ca2+ signal transduction is essential for several aspects of glutamatergic synaptic plasticity. The enzyme consists of four different chains: α; β; γ and δ. The alpha chain encoded by this gene is necessary for long-term hippocampus (LTP) and spatial learning. [Citation needed] In addition to its calcium-calmodulin (CaM)-dependent activity; the protein can also undergo autophosphorylation; resulting in CaM-independent activity. Two transcript variants encoding different isoforms have been identified for this gene.

Gene ID

815(Human);12322(Mouse)

Uniprot ID

Q9UQM7(Human)