C9orf72 shRNA Plasmid Expression Vector Set

Name: C9orf72 shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY345
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY345]

Target:: C9orf72

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Product Overview

Description

A specialized kit for the targeted knockdown of the C9orf72 gene, the most common genetic cause of ALS and FTD. The set includes three distinct shRNA plasmid vectors designed to target C9orf72 mRNA for potent silencing, along with a scrambled shRNA plasmid as a negative control. This kit is crucial for dissecting the complex pathogenic mechanisms of the C9orf72 repeat expansion.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

C9orf72

Full Name

RNA-Binding Protein FUS

Alternative Names

TLS

Gene ID

2521

Uniprot ID

P35637

Target Overview

FUS (Fused in Sarcoma) is a DNA/RNA-binding protein that is predominantly located in the nucleus and plays a crucial role in various aspects of RNA metabolism, including transcription, pre-mRNA splicing, and RNA transport. FUS is strongly linked to neurodegenerative disease; mutations in the FUS gene are a known cause of familial Amyotrophic Lateral Sclerosis (ALS). In these diseases, a key pathological feature is the mislocalization of the FUS protein from the nucleus to the cytoplasm, where it forms insoluble aggregates. These FUS-positive inclusions are hallmarks of certain forms of ALS and Frontotemporal Lobar Degeneration (FTLD-FUS).

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