NoGeneST™ Anti-PSEN2 Aptamer, aPSEN2 aptamer

Name: NoGeneST™ Anti-PSEN2 Aptamer, aPSEN2 aptamer
SKU: NRYF-0625-HZ86
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ86]

Aptamer designed to specifically recognize Presenilin-2, a catalytic component of the gamma-secretase complex involved in Alzheimer's disease.

Target:: PSEN2

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Product Overview

Species

Human

Relevant Diseases

Alzheimer's Disease

Properties

Size

5 nmol. 10 nmol. 50 nmol

Soluble In

PBS; buffer system with Serum; other

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

PSEN2

Full Name

Presenilin-2

Gene ID

5664

Uniprot ID

P49810

Target Overview

Presenilin-2 is a multi-pass transmembrane protein that is highly homologous to Presenilin-1. It serves as an essential catalytic subunit of the gamma-secretase complex, an intramembrane protease. This complex executes the final cleavage of the Amyloid Precursor Protein (APP) to generate different species of Amyloid-beta (Aβ) peptides. Mutations in the PSEN2 gene are a known cause of early-onset, inherited Alzheimer's disease (AD4), albeit less common than mutations in PSEN1. Its direct involvement in Aβ production makes it a key protein in the pathology of Alzheimer's.

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