NoGeneST™ USH2A-ASO, Antisense Oligonucleotide

Name: NoGeneST™ USH2A-ASO, Antisense Oligonucleotide
SKU: NRYF-0625-XY58
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-XY58]

Target:: USH2A

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Product Overview

Description

USH2A-ASO is a single-stranded RNA-based oligonucleotide designed to skip exon 13 in the RNA, aiming to halt vision loss in individuals with retinitis pigmentosa caused by an exon 13 mutation in the USH2A gene (which encodes usherin).

Species

Human

Applications

Corrects splicing defects in USH2A mutations linked to Usher syndrome (deafness and retinitis pigmentosa). In neuroscience, investigates USH2A's role in inner ear hair cell synapses and photoreceptor-neuron interactions. Enables preclinical testing of exon skipping strategies for genetic hearing/vision loss.

Relevant Diseases

Retinitis pigmentosa

Properties

Appearance

Solid

Shipping

Room temperature

Storage

Store at -20°C, sealed and away from moisture.
In solvent, store at -80°C for up to 6 months, or -20°C for up to 1 month (sealed and away from moisture).