SCNA shRNA Plasmid Expression Vector Set

Name: SCNA shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY334
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY334]

Target:: SNCA

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Inquiry

Product Overview

Description

An essential research kit for the targeted knockdown of the Alpha-Synuclein (SCNA) gene, the primary component of Lewy bodies in Parkinson's disease. The set provides three validated shRNA plasmid vectors, each targeting a different sequence of the SCNA mRNA, plus a scrambled shRNA plasmid as a negative control. It is an indispensable tool for investigating α-synuclein aggregation, toxicity, and its role in neurodegeneration.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

SNCA

Full Name

Alpha-Synuclein

Gene ID

6622

Uniprot ID

P37840

Target Overview

Alpha-synuclein (encoded by the SNCA gene) is a protein that is abundant in the human brain, where it is found primarily at the tips of neurons in specialized structures called presynaptic terminals. Although its exact function is not fully understood, it is thought to play a role in regulating the release of neurotransmitters. Alpha-synuclein is most notable for its central role in a group of neurodegenerative disorders known as "synucleinopathies." In these diseases, the protein misfolds and aggregates into insoluble fibrils that accumulate in neurons as Lewy bodies and Lewy neurites. These aggregates are the defining pathological hallmark of Parkinson's disease, dementia with Lewy bodies (DLB), and multiple system atrophy (MSA).

Publications