HTT shRNA Plasmid Expression Vector Set

Name: HTT shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY338
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY338]

Target:: HTT

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Product Overview

Description

A highly effective kit for the targeted knockdown of the Huntingtin (HTT) gene to model Huntington's disease. The set provides three validated shRNA plasmid vectors targeting different sequences of the HTT mRNA for potent gene suppression, accompanied by a scrambled shRNA plasmid as a negative control. This is an invaluable tool for studying the toxic effects of the mutant HTT protein and testing gene-silencing therapies.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

HTT

Full Name

Huntingtin

Alternative Names

HD; IT15

Gene ID

3064

Uniprot ID

P42858

Target Overview

Huntingtin (HTT) is a large protein that is required for normal embryonic development and is widely expressed in the body, with the highest concentrations in the brain. It is involved in various crucial cellular functions, including vesicle trafficking, endocytosis, and the regulation of transcription. The HTT protein is most notable for its central role in Huntington's disease, a progressive neurodegenerative disorder. The disease is caused by a specific genetic mutation: an expansion of a CAG trinucleotide repeat in the HTT gene, which results in an abnormally long polyglutamine tract in the Huntingtin protein. This mutation causes the protein to misfold and aggregate, leading to neuronal dysfunction and death.

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