NoGeneST™ Anti-HTT Aptamer, aHTT aptamer

Name: NoGeneST™ Anti-HTT Aptamer, aHTT aptamer
SKU: NRYF-0625-HZ95
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ95]

Aptamer designed to specifically recognize Huntingtin, the protein whose mutation causes Huntington's disease.

Target:: HTT

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Product Overview

Relevant Diseases

Huntington's Disease

Properties

Size

5 nmol. 10 nmol. 50 nmol

Soluble In

PBS; buffer system with Serum; other

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

HTT

Full Name

Huntingtin

Alternative Names

HD; IT15

Gene ID

3064

Uniprot ID

P42858

Target Overview

Huntingtin (HTT) is a large protein that is required for normal embryonic development and is widely expressed in the body, with the highest concentrations in the brain. It is involved in various crucial cellular functions, including vesicle trafficking, endocytosis, and the regulation of transcription. The HTT protein is most notable for its central role in Huntington's disease, a progressive neurodegenerative disorder. The disease is caused by a specific genetic mutation: an expansion of a CAG trinucleotide repeat in the HTT gene, which results in an abnormally long polyglutamine tract in the Huntingtin protein. This mutation causes the protein to misfold and aggregate, leading to neuronal dysfunction and death.

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