Product

Human HEK293/FP/Gα15 Stable Cell Line

[CAT#: NCL20120118CR]

FP Prostanoid Receptor Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: HEK293; GPCR Cell

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Product Overview

Description

It is involved in modulating intraocular pressure and smooth muscle contraction in uterus. Its effects on cells are mediated through specific interaction with the Prostanoid receptor FP, which is a 359-amino acid protein. Having 7 putative transmembrane domains, FP resembles the characteristic of G protein coupled receptors. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thereupon induce luteolysis.

Cell Types

HEK293; GPCR Cell

Applications

GPCR Screening

Research Areas

GPCR; Neural Cell

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

DMEM, 10% FBS, 200 μg/ml Zeocin, 250 μg/ml G418, 100 μg/ml Hygromycin B

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

FP/PTGFR

Family

Prostanoid receptor

Strain

FP/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

Official Name

Alternative Names

FP receptor; prostaglandin F; FP; PF2AR; PGF receptor; PGF2 alpha receptor; PGF2-alpha receptor; prostaglandin F receptor; prostaglandin F2-alpha receptor; prostanoid FP receptor; PGF; AI957154

Gene ID

2224(Human)

Uniprot ID

P14324(Human)

References

1. Montagna, E., Crux, S., Luckner, M., Herber, J., Colombo, A. V., Marinković, P.,.. & Sgobio, C. (2019). In vivo Ca2+ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondria. Glia, 67(5), 985-998. 2. Xu, Y., Wu, X., Wang, S., Yang, C., Li, Y., & Cao, Y. (2019). Hydroxyapatite Nanoparticle-Crosslinked Peptide Hydrogels for Three-Dimensional Culture and Differentiation of MC3T3-E1 Osteoblasts. Journal of biomedical nanotechnology, 15(12), 2351-2362. 3. Lan, J., Rollins, J. A., Zang, X., Wu, D., Zou, L., Wang, Z.,.. & Chen, D. (2019). Translational regulation of non-autonomous mitochondrial stress response promotes longevity. Cell reports, 28(4), 1050-1062.

Publications