Mouse Anti-Clusterin Monoclonal Antibody (CBP1932)

Description

The mouse anti-human cluster protein antibody recognizes cluster protein, which is a ubiquitously expressed protein of two 40 kDa chains α and β covalently linked by disulfide bonds. It exists in two forms: a pro-apoptotic form located in the nucleus and a secreted form that promotes survival. Both are thought to be related to DNA repair and cell cycle regulation. It is believed that this form of secretion can inhibit apoptosis signal transduction through BAX, and the inhibitory effect of Clusterin can make cells sensitive to chemotherapy. Clusterin is overexpressed in human prostate cancer, breast cancer and squamous cell carcinoma.
Clusterin is part of the SC5b-9 complex and prevents the C5b-C7 complex from binding to the target cell membrane, thereby inhibiting the complement cascade. Clusterin acts as an extracellular chaperone, inhibiting the formation of human lysozyme amyloid associated with Alzheimer's disease. Clusterin is also important in spermatogenesis and is secreted by supporting cells.

Immunogen

The glomerular basement membrane of the kidney after death.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP1932

Applications

ELISA; WB; FC; IHC-Fr

Relevant Diseases

Alzheimer's Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated

Form

Liquid

Formulation

0.1% Sodium Azide

Preservatives

Yes

Concentration

1.0 mg/ml

Purification

Purified IgG prepared by affinity chromatography on Protein A.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred.

This product should be stored undiluted.

Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Clusterin

Official Name

CLU

Full Name

Clusterin

Alternative Names

Clusterin; Testosterone-Repressed Prostate Message 2; Apolipoprotein J; Complement-Associated Protein SP-40,40; Complement Cytolysis Inhibitor; Complement Lysis Inhibitor; Sulfated Glycoprotein 2; Ku70-Binding Protein 1; NA1/NA2; TRPM-2; APO-J; APOJ; KUB1

Gene ID

1191(Human); 12759(Mouse); 24854(Rat)

Uniprot ID

P10909(Human); Q06890(Mouse); P05371(Rat)

1. Kumita, J.R. et al. (2007) The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species.
2. Shannan, B. et al. (2006) Clusterin and DNA repair: a new function in cancer for a key player in apoptosis and cell cycle control.