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Creative Biolabs
Product

NeuroMab™ Rat Anti-Mouse Apolipoprotein E Monoclonal Antibody (CBP2304)

[CAT#: NAB2010249LS]

Anti-Apolipoprotein E Monoclonal Antibody [PE]

Host Species:
Rat
Species Reactivity:
Mouse
Applications:
FC

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Product Overview

Description

Apo-E is a class of apolipoprotein primarily synthesized in the liver, but is also found in other tissues such as brain, kidneys, and spleen. Apo-E is a protein component of serum chylomicron and lipoprotein particles, playing essential roles in cholesterol transportation, homeostasis, and metabolism. The expression of Apo-E is induced by cholesterol-rich diets and hyperlipoproteinemia. In the central nervous system, Apo-E is produced by astrocytes and microglia. The Apo-E-containing lipoprotein particles play important functions in brain injury repair, neurogenesis, and synaptic plasticity. Apo-E has been found to be involved in the regulation of amyloid-β aggregation and clearance. Genetic polymorphisms of Apo-E are associated with neuron degenerative disorders including Alzheimer's disease.

Immunogen

This antibody was raised against a synthetic peptide corresponding to amino acids surrounding the polymorphic amino acid position 158 of Apo-E.

Species Reactivity

Mouse

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG1, κ

Clone Number

CBP2304

Applications

FC

Application Notes

FCM (5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1696
Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.

Concentration

Batch Dependent

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Handling Advice

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Research Use Only

For research use only, not for diagnostic or therapeutic use.
Target

Target

Apo E

Official Name

APOE

Full Name

Apolipoprotein E

Alternative Names

APOE; AD2; APO-E; LDLCQ5; LPG; apolipoprotein E; ApoE4

Gene ID

348 (Human); 11816 (Mouse)

Uniprot ID

P02649 (Human); P08226 (Mouse)
Publications

Publications (0)

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