Mouse Anti-JNK Monoclonal Antibody (CBP2715)

Product Overview

Description

JNK1 is a serine/threonine-protein kinase. It is an important player in signaling transduction pathways governing cellular response to external stimuli, including ultraviolet radiation (UV), inflammatory cytokines, and reactive oxygen species (ROS). JNK1 phosphorylates several transcription factors, such as c-Jun, Elk-1, and ATF2, affecting their transcription activity.

Expression Host

Mammalian cells

Immunogen

JNK fusion protein Ag21426

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2715

Applications

IF; IHC; WB; ELISA

Application Notes

IF : 1:20-1:200; IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Neural Cell

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

800 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

JNK

Official Name

JNK

Full Name

Mitogen-activated protein kinase 8

Alternative Names

AI849689;
c Jun N terminal kinase 1;
C-JUN kinase 1;
c-Jun N-terminal kinase 1;
EC 2.7.11.24;
JNK 1;
JNK;

Gene ID

5599(Human); 26419(Mouse); 116554(Rat)

Uniprot ID

P45983(Human); Q91Y86(Mouse); P49185(Rat)

References

1. Ren, Z., Chen, L., Wang, Y., Wei, X., Zeng, S., Zheng, Y.,... & Liu, H. (2019). Activation of the omega-3 fatty acid receptor GPR120 protects against focal cerebral ischemic injury by preventing inflammation and apoptosis in mice. The Journal of Immunology, 202(3), 747-759. 2. Li, S., Huang, Q., Zhang, L., Qiao, X., Zhang, Y., Tang, F., & Li, Z. (2019). Effect of CAPE-pNO2 against type 2 diabetes mellitus via the AMPK/GLUT4/GSK3β/PPARα pathway in HFD/STZ-induced diabetic mice. European journal of pharmacology, 853, 1-10. 3. Tian, L., Su, C. P., Wang, Q., Wu, F. J., Bai, R., Zhang, H. M.,... & Guo, S. Z. (2019). Chlorogenic acid: A potent molecule that protects cardiomyocytes from TNF-α-induced injury via inhibiting NF-κB and JNK signals. Journal of cellular and molecular medicine, 23(7), 4666-4678.

Publications