Mouse Anti-DAG1 Monoclonal Antibody (CBP2839)

Product Overview

Description

Dystroglycan was originally isolated from skeletal muscle as an integral membrane component of the dystrophin-glycoprotein complex (DGC). In addition to skeletal muscle, dystroglycan is strongly expressed in heart and smooth muscle, as well as many non-muscle tissues including brain and peripheral nerve (PMID: 12556455). The dystroglycan is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Dystroglycan consists of two subunits (alpha and beta), which are translated from a single mRNA as a propeptide that is proteolytically cleaved into two noncovalently associated proteins.

Expression Host

Mammalian cells

Immunogen

Dystroglycan fusion protein Ag27222

Species Reactivity

Human; Mouse; Rat; Porcine

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2839

Applications

FC; IHC; WB; ELISA

Application Notes

IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Neural Signal Transduction

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

DAG1

Official Name

DAG1

Full Name

Dystroglycan 1

Alternative Names

156DAG; A3a; AGRNR; Alpha DG Beta dystroglycan; Beta DG; DAG; DAG1; Dystroglycan

Gene ID

1605(Human); 13138(Mouse); 114489(Rat)

Uniprot ID

Q14118(Human); Q62165(Mouse)

References

1. Sarute, N., & Ross, S. R. (2020). CACNA1S haploinsufficiency confers resistance to New World arenavirus infection. Proceedings of the National Academy of Sciences, 117(32), 19497-19506.

Publications