Anti-Cofilin 1 Monoclonal Antibody (CBP3733)

Product Overview

Description

Cofilin 1 is a ubiquitously expressed actin-regulating protein that binds to and depolymerizes filamentous actin (F-actin), as well as inhibits G-actin polymerization in a pH-dependent mechanism. Cofilin 1 plays a major role in cell migration, particularly tumor cell migration and invasion.

Immunogen

Human CFL1 recombinant protein (a.a. Met 1-Leu 166)

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP3733

Applications

WB; IHC-P; ICC

Application Notes

WB (2.0-10 µg/mL); IHC (1.0- 5.0 µg/mL); ICC (2.0- 10.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Cofilin 1

Official Name

CFL1

Full Name

Cofilin 1

Alternative Names

CFL1; Cofilin 1

Gene ID

1072(Human); 12631(Mouse); 29271(Rat)

Uniprot ID

P23528(Human); P18760(Mouse); P45592(Rat)

References

1. Kanellos G and Frame MC. 2016. J Cell Sci. 129(17):3211
2. Walsh KP, et al. 2014. Prion. 8(6):375
3. Xu P, et al. 2018. Front Plant Sci. 9:1528
4. Mousavi S, et al. 2018. J Gastrointest Oncol. 9(5):791

Publications