Mouse Anti-SOD3 Monoclonal Antibody (CBP4235)

Description

Superoxide dismutase (SOD) is an antioxidant enzyme that participates in the defense system against reactive oxygen species (ROS). SOD catalyzes the disproportionation of superoxide radical anions (O2-) into hydrogen peroxide, which is then catalyzed into non-toxic O2 and H2O by glutathione peroxidase and catalase. Several types of SOD have been identified. These include intracellular copper, zinc superoxide dismutase (Cu, Zn-SOD/SOD-1), mitochondrial manganese superoxide dismutase (Mn-SOD/SOD-2) and extracellular copper, zinc superoxide dismutase Enzyme (EC-SOD / SOD-3). SOD1 exists in the form of a 32 kDa homodimer enzyme in all eukaryotes, and each subunit contains a Cu and Zn ion. Manganese containing 80 kDa tetramer enzyme SOD2 is located in the mitochondrial matrix, next to the main endogenous superoxide source (mitochondrial respiratory chain). SOD3 is a heparin-binding polymer of disulfide-linked dimers, which is mainly expressed in human lungs, blood vessel walls and airways. SOD4 is a copper molecular chaperone for superoxide dismutase (CCS), which specifically delivers Cu to copper/zinc superoxide dismutase. CCS can activate copper/zinc superoxide dismutase by directly inserting Cu cofactors. SOD3 protects the extracellular space from the toxic effects of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.

Immunogen

Recombinant human protein purified from E. coli

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP4235

Applications

WB; IHC-P; IP; ELISA

Application Notes

WB: 1:2000, IP: 1 µl

Conjugation

Unconjugated

Form

Colorless liquid

Formulation

100 µl of antibody in HEPES with 0.15 M NaCl, 0.01 % BSA, 0.03 % sodium azide, and 50 % glycerol

Preservatives

Yes

Shipping

Gel Pack

Storage

-20°C

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

SOD3

Official Name

SOD3

Full Name

Superoxide Dismutase 3

Alternative Names

Superoxide Dismutase 3; Superoxide Dismutase 3, Extracellular; EC 1.15.1.1; EC-SOD; Extracellular Superoxide Dismutase [Cu-Zn]; Testicular Tissue Protein Li 175

Gene ID

6649(Human); 20657(Mouse)

Uniprot ID

P08294(Human); O09164(Mouse)