Mouse Anti-ITGAM Monoclonal Antibody (CBP6771)

Description

Neuroinflammation is locally produced in the central nervous system through phenotypic changes of different non-neuronal cell types (such as microglia, oligodendrocytes, and astrocytes) in the brain, leading to different cytokines and chemokines The release of C, eventually recruits and infiltrates peripheral blood cells, mainly T-and B cells, into the brain parenchyma. Integrin αM (ITGAM) is a protein subunit that can form heterodimeric integrin α-Mbeta-2 (αMβ2) molecules, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). ITGAM, also known as CR3A, is a cluster of differentiation molecules 11B (CD11B). The second chain of αMβ2 is a common integrin β2 subunit called CD18, so integrin αMβ2 belongs to the β2 subfamily (or leukocyte) integrin.

αMβ2 is expressed on the surface of many white blood cells involved in the innate immune system, including monocytes, granulocytes, macrophages and natural killer cells. It mediates inflammation by regulating the adhesion and migration of leukocytes, and is related to various immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cell activation. It participates in the complement system because it has the ability to bind the inactivated complement component 3b (iC3b). The ITGAMα subunit of integrin αMβ2 is directly involved in causing cell adhesion and spreading, but if β2 (CD18) subunit is not present, it cannot mediate cell migration.

Epitope

Binds to an located within the peptide sequence RIQCDIPFFG

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP6771

Applications

IHC; WB

Application Notes

IHC: 1:1000-1:2500
WB: 1 µg/ml

Marker

Glial Cell Markers; Microglia Markers

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

0.1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

CD11b

Official Name

ITGAM

Full Name

Integrin alpha M

Alternative Names

ITGAM; CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6; integrin subunit alpha M

Gene ID

3684 (Human); 16409 (Mouse); 25021 (Rat)

Uniprot ID

P11215 (Human); P05555 (Mouse)