Human HEK293/EP1 Stable Cell Line

[CAT#: NCL20120116CR]

EP1 Prostanoid Receptor Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

Prostaglandin E2 receptor, EP1 subtype (EP1/PTGER1) is a receptor for prostaglandin E2 (PGE2). The members of the EP receptor family, EP1, EP2, EP3, and EP4, elicit their actions by altering cyclic adenosine monophosphate (cAMP) or intracellular calcium concentrations. EP1 activates phospholipase C and phosphatidylinositol turnover and stimulates the release of intracellular calcium via a Gi/Gq-coupled mechanism. EP2 and EP4 both signal through a Gs-coupled mechanism that stimulates adenylyl cyclase and increases intracellular levels of cAMP.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR; Neural Cell

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

DMEM, 10% FBS, 200 μg/ml Zeocin, 250 μg/ml G418

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

EP1/PTGER1

Family

Prostanoid receptor

Strain

EP1 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

EP1

Official Name

EP1

Alternative Names

EP1 receptor; prostaglandin E; EP1; prostaglandin E receptor 1 (subtype EP1); 42kD; EP1 prostanoid receptor; PGE receptor EP1 subtype; PGE receptor; EP1 subtype; PGE2 receptor EP1 subtype; prostaglandin E receptor 1; prostaglandin E receptor 1 (subtype EP1); prostaglandin E receptor EP1 subtype; prostaglandin E2 receptor EP1 subtype; prostanoid EP1 receptor; Ptgerep1; 42kDa

Gene ID

5731(Human); 19216(Mouse)

Uniprot ID

P34995(Human); P35375(Mouse)

References

1. Montagna, E., Crux, S., Luckner, M., Herber, J., Colombo, A. V., Marinković, P.,.. & Sgobio, C. (2019). In vivo Ca2+ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondria. Glia, 67(5), 985-998. 2. Xu, Y., Wu, X., Wang, S., Yang, C., Li, Y., & Cao, Y. (2019). Hydroxyapatite Nanoparticle-Crosslinked Peptide Hydrogels for Three-Dimensional Culture and Differentiation of MC3T3-E1 Osteoblasts. Journal of biomedical nanotechnology, 15(12), 2351-2362. 3. Lan, J., Rollins, J. A., Zang, X., Wu, D., Zou, L., Wang, Z.,.. & Chen, D. (2019). Translational regulation of non-autonomous mitochondrial stress response promotes longevity. Cell reports, 28(4), 1050-1062.

Publications