Mouse Anti-MAPT Monoclonal Antibody (CBP4065)

Product Overview

Description

Tau is a microtubule binding protein that stabilizes microtubules in growing axons. It was found that Tau is hyperphosphorylated in paired spiral filaments (PHF), which is the main fibrous component of neurofibrillary disease associated with Alzheimer's disease. The hyperphosphorylation of Tau is considered to be a key event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK3. This indicates that the misdirection of GSK3 signal transduction may lead to the onset of Alzheimer's disease.

Immunogen

A synthetic peptide corresponding to amino acids 15-25 on the longest isomer of human Tau

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP4065

Applications

Application Notes

WB: 1:500-1:1000

Conjugation

Unconjugated

Product Properties

Form

colorless liquid

Formulation

100 µl undiluted mouse ascites fluid

Preservatives

BSA free

Purification

Affinity purified

Shipping

Gel Pack

Storage

-20°C

Handling Advice

The antibody solution should be gently mixed before use.

Target

Tau

Official Name

MAPT

Full Name

Microtubule Associated Protein Tau

Alternative Names

Microtubule Associated Protein Tau; G Protein Beta1/Gamma2 Subunit-Interacting Factor 1; Protein Phosphatase 1; Regulatory Subunit 103; Neurofibrillary Tangle Protein; Paired Helical Filament-Tau; PHF-Tau; MAPTL; MTBT1; TAU