Human Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils (PFFs) for Alzheimer's Disease Modeling

Name: Human Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils (PFFs) for Alzheimer's Disease Modeling
SKU: NRYF-0826-CW106
Rating: 5 (1 reviews)

[CAT#: NRYF-0826-CW106]

Species:: Human

Expression System:: Chemical Synthesis

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Product Overview

Description

A synthetic human amyloid-β pe3-42 pre-formed fibril preparation designed for Alzheimer's Disease modeling.

Species

Human

Protein Length

40 aa (residues 3-42)

Applications

EM; FuncS; SDS-PAGE

Molecular Weight

4.2 kDa (monomer)

Target

Target Protein

Amyloid Beta

Synonym

Aβ; Beta-Amyloid; APP; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; preA4; CTFgamma; alpha-sAPP

Research Areas

Neurodegeneration; Protein Aggregation; Alzheimer's Disease

Introduction

N-terminally truncated pyroglutamate-modified amyloid beta species are abundant in Alzheimer's disease plaques and display enhanced stability, aggregation, and neurotoxic potential. This product contains human amyloid beta pyroglutamate 3-42 pre-formed fibrils for modeling modification-specific amyloid pathology. For research use only.

Gene ID

351

Uniprot ID

P05067

Properties

Buffer

10 mM HCl, cotaining 2% DMSO

Storage

-80°C

Shipping

Dry ice

Quality Control

Transmission electron microscopy (TEM) and atomic force microscopy (AFM) confirm uniform fibrillar morphology; Thioflavin T (ThT) assay verifies robust β-sheet-rich aggregation; analytical purity testing confirms high purity and expected molecular species profile.

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