Mouse Anti-Human DNMT1 Monoclonal Antibody (CBP3751)

Product Overview

Description

DNA (Cytisube-5-)-Methyltransferase 1 (DNMT-1), is an enzyme that has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. This enzyme associates with DNA replication sites in the S phase and methylates CpG residues to maintain the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance.

Immunogen

Partial human DNMT1 recombinant protein (1-200 a.a.) expressed in E. coli.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP3751

Applications

Application Notes

WB (0.5-2.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.

Concentration

Batch Dependent

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

DNMT1

Official Name

DNMT1

Full Name

DNA (cytosine-5-)-methyltransferase 1

Alternative Names

ADCADN;
AIM;
CXXC finger protein 9;
CXXC-type zinc finger protein 9;
CXXC9;
DNA (cytosine 5) methyltransferase 1;
DNA (cytosine-5)-methyltransferase 1;
DNA methyltransferase 1;
DNA methyltransferase HsaI;
DNA methyltransferase M.HsaI.;

Uniprot ID

P26358(Human); P13864(Mouse); Q9Z330(Rat)

References

1. Merry CR, et al. 2015. Hum. Mol. Genet. 24:6240.
2. Cheng J, et al. 2015. Nat. Commun. 6:7023.
3. Pathania R, et al. 2015. Nat. Commun. 6:6910.
4. Liao J, et al. 2015. Nat. Genet. 47:469.
5. Espada J. 2012. Epigenetics 7:115.
6. SvedruÅ¾iÄ‡ Å½M. 2011. Prog. Mol. Biol. Transl. Sci. 101:221.

Publications