Product
Mouse Anti-Human DNMT1 Monoclonal Antibody (CBP3751)
[CAT#: NAB2012137LS]
Anti-DNMT1 Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- WB
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
DNA (Cytisube-5-)-Methyltransferase 1 (DNMT-1), is an enzyme that has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. This enzyme associates with DNA replication sites in the S phase and methylates CpG residues to maintain the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance.
Immunogen
Partial human DNMT1 recombinant protein (1-200 a.a.) expressed in E. coli.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1, κ
Clone Number
CBP3751
Applications
WB
Application Notes
WB (0.5-2.0 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.
Concentration
Batch Dependent
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
DNMT1
Official Name
DNMT1
Full Name
DNA (cytosine-5-)-methyltransferase 1
Alternative Names
ADCADN;
AIM;
CXXC finger protein 9;
CXXC-type zinc finger protein 9;
CXXC9;
DNA (cytosine 5) methyltransferase 1;
DNA (cytosine-5)-methyltransferase 1;
DNA methyltransferase 1;
DNA methyltransferase HsaI;
DNA methyltransferase M.HsaI.;
AIM;
CXXC finger protein 9;
CXXC-type zinc finger protein 9;
CXXC9;
DNA (cytosine 5) methyltransferase 1;
DNA (cytosine-5)-methyltransferase 1;
DNA methyltransferase 1;
DNA methyltransferase HsaI;
DNA methyltransferase M.HsaI.;
References
1. Merry CR, et al. 2015. Hum. Mol. Genet. 24:6240.
2. Cheng J, et al. 2015. Nat. Commun. 6:7023.
3. Pathania R, et al. 2015. Nat. Commun. 6:6910.
4. Liao J, et al. 2015. Nat. Genet. 47:469.
5. Espada J. 2012. Epigenetics 7:115.
6. Svedružić ŽM. 2011. Prog. Mol. Biol. Transl. Sci. 101:221.
2. Cheng J, et al. 2015. Nat. Commun. 6:7023.
3. Pathania R, et al. 2015. Nat. Commun. 6:6910.
4. Liao J, et al. 2015. Nat. Genet. 47:469.
5. Espada J. 2012. Epigenetics 7:115.
6. Svedružić ŽM. 2011. Prog. Mol. Biol. Transl. Sci. 101:221.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
