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Creative Biolabs
Product

Mouse Anti-Human Synuclein-α/β 130-140 Monoclonal Antibody (CBP3952)

[CAT#: NAB2012882LS]

Anti-Synuclein-α/β 130-140 Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IHC-P; WB; FC; ICC; IP

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Product Overview

Description

Synucleins are small soluble proteins expressed primarily in neural tissues and in certain tumors. The family includes 3 known proteins, alpha synuclein, beta synuclein and gamma synuclein. All synucleins have in common a highly conserved alpha helical lipid binding motif with similarity to the class-A2 lipid binding domains of the exchangeable apolipoproteins. The alpha and beta synuclein proteins are found primarily in brain tissue, where they are seen mainly in pre-synaptic terminals. Alpha synuclein is believed to be a major component of Lewy bodies in Parkinson's disease. Mutations in alpha synuclein are associated with rare familial cases of early onset Parkinson's disease, Alzheimer's disease and several other neurodegenerative illnesses.

Immunogen

Syn 202 was raised using recombinant alpha and beta synucleins and recognizes residues 130-140 in alpha and beta synuclein.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP3952

Applications

IHC-P; WB; FC; ICC; IP

Application Notes

IHC (1:500-1:1000); WB (1:500-1:1000)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated
Product Properties

Form

Liquid

Formulation

Ascites Fluid (contains 0.01M sodium azide).

Concentration

Batch Dependent

Purification

Unpurified

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at-20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.
Target

Target

Alpha Synuclein

Official Name

SNCA

Full Name

Alpha-synuclein

Alternative Names

CD14

Gene ID

6622 (Human); 20617 (Mouse)
Publications

Publications (0)

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