NoGeneST™ Anti-BACE1 Aptamer, aBACE1 aptamer

Name: NoGeneST™ Anti-BACE1 Aptamer, aBACE1 aptamer
SKU: NRYF-0625-HZ84
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ84]

Aptamer designed to specifically recognize Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1, a key protease in the amyloidogenic pathway of Alzheimer's disease.

Target:: BACE1

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Product Overview

Species

Human

Relevant Diseases

Alzheimer's Disease

Properties

Size

5 nmol. 10 nmol. 50 nmol

Soluble In

PBS; buffer system with Serum; other

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

BACE1

Full Name

Beta-secretase 1

Gene ID

23621

Uniprot ID

P56817

Target Overview

Beta-secretase 1 (BACE1) is an aspartic protease that functions as the primary beta-secretase enzyme in the brain. Its most critical and widely studied role is performing the initial proteolytic cleavage of the Amyloid Precursor Protein (APP). This enzymatic cut is the first and rate-limiting step in the pathway that produces Amyloid-beta (Aβ) peptides. The subsequent aggregation of Aβ peptides into plaques is a central pathological hallmark of Alzheimer's disease. Therefore, BACE1 is considered a prime therapeutic target for reducing Aβ production and slowing the progression of the disease.

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