SMN2 shRNA Plasmid Expression Vector Set

Name: SMN2 shRNA Plasmid Expression Vector Set
SKU: NRYF-0925-XY347
Rating: 5 (1 reviews)

[CAT#: NRYF-0925-XY347]

Target:: SMN2

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Product Overview

Description

A critical kit for the specific knockdown of the Survival Motor Neuron 2 (SMN2) gene, the primary therapeutic target for SMA. The set provides three validated shRNA plasmid vectors targeting SMN2 mRNA for robust suppression, along with a scrambled shRNA plasmid as a negative control. This is an essential tool for researchers developing and testing therapies designed to modulate SMN2 splicing.

Properties

Size

5-50 μg

Shipping

Ambient

Storage

4°C

Research Use Only

Target Details

Target

SMN2

Full Name

Survival Motor Neuron Protein

Alternative Names

SMN; SMNT

Gene ID

6606

Uniprot ID

Q16637

Target Overview

Survival Motor Neuron Protein SMN1 is a protein that is essential for the survival of all cells, with a particularly critical role in motor neurons. It is a key component of a complex responsible for the assembly of small nuclear ribonucleoproteins (snRNPs), which are the fundamental building blocks of the spliceosome. The spliceosome carries out pre-mRNA splicing, a crucial step in gene expression. The loss of the SMN1 gene through homozygous deletion or mutation leads to a deficiency of functional SMN protein. This deficiency is the direct cause of Spinal Muscular Atrophy (SMA), a severe and progressive neuromuscular disease.

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